Multidrug resistance (MDR) to chemotherapeutic drugs remains one of the major impediments to the treatment of cancer.Discovery and development of drugs that can prevent and reverse the acquisition of multidrug resistance constitute a foremost challenge in cancer therapeutics.In this work, we screened a library of 1,127 compounds with known targets
Abstract Background Secondary contact between closely related lineages can result in a variety of outcomes, including hybridization, depending upon the strength of reproductive barriers.By examining the extent to which different parts of the genome introgress, it is possible to infer the strength of selection and gain insight into the evolutionary
This article presents a model for Customer Lifetime Value (CLV) tailored to the subscription-based streaming industry, incorporating both contractual dynamics and user activity.Unlike traditional CLV models that Body Oil overlook contracts, this semi-Markov model captures the time users remain in specific subscription plans and the transitions betw
Ultraviolet (UV) radiation has been considered a deleterious agent that living organisms must avoid.However, many of the acclimation changes elicited by UV induce a wide range of positive effects in plant physiology through the elicitation of secondary antioxidant metabolites and natural defenses.Therefore, this fact has changed the original UV con